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Human macrophages have been engineered to ignore the 'don't eat me' signal both healthy and cancerous cells exhibit. Combined with cancer-specific targeting antibodies, these engineered macrophages invaded and engulfed human tumor cells in a mouse model.
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Genetically modified “hunter” T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex…
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An international consortium completed a landmark study of most common pediatric brain tumor, revealing new cancer genes, laying the foundation to expand precision medicine.
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How well cancer patients fared after chemotherapy was affected by their social interaction with other patients during treatment, according to a new study. Cancer patients were a little more likely to survive for five years or more after chemotherapy if…
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A key new mechanism has been identified that regulates the ability of T-cells of the immune system to react against foreign antigens and cancer.
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In the case of glioblastoma multiforme, the deadliest type of brain cancer, researchers have discovered that the molecule CD44s seems to give cancer cells a survival advantage. In the lab, eliminating this advantage by reducing the amount of CD44s resulted…
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Researchers report a new, previously unrecognized function of the BRCA1 gene that explains why BRCA1 gene mutation carriers are at increased risk of breast and ovarian cancer.
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Two cell types work together to protect pancreatic tumors from destruction by the immune system. But, blocking this partnership may restore the system's ability to attack these same tumor cells, report scientists.
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A genome sequencing approach has been used to reveal the 'drivers' of adaptation in laboratory-evolved yeast. This work uncovers roles of genetic hitchhiking and interaction in determining which mutations succeed or fail in rapidly-evolving microbial population and may hold clues…
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Treatment for osteoporosis may also help prevent gum disease, according to new research that examined the prevalence of periodontitis in postmenopausal women.
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Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumors that are resistant to further chemotherapy. At this point, the…
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An engineer created surgery-tested software that better marries CT scan images of the liver with a tracked tool's.
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Scientists have teamed up to evaluate the tools used to probe the cancer genome. Their work classifies and describes the strengths and weaknesses of more than 20 algorithms developed by independent research groups.
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Investigators have developed and tested an innovative, reliable means of analyzing pre-cancerous breast lesions diagnosing certain kidney diseases and using only a conventional light microscope. The technique – dubbed “expansion pathology or ExPath – enhances pathologists’ diagnostic ability and could…
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Patients who have neoadjuvant radiation therapy have a significantly lower risk of developing a second primary tumor at any site, report investigators.
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Scientists have identified a role for the HDAC11 enzyme in the regulation of T-cell function. The team found that HDAC11 should be treated as an immunotherapeutic target.
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A new study solidifies an important role for both TLK1 and TLK2 in genome stability. This work is also the first to report on the key role of the TLK2 gene in mouse embryo development.
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Researchers have patented a portable device that can detect tumor cells in blood. The device counts the number of tumor cells in a blood sample and is a highly effective tool for improving the monitoring, treatment and diagnosis of cancer.
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Many patients with melanoma need a sentinel-lymph-node biopsy to determine if cancer cells have spread there, but a positive finding doesn't mean all the lymph nodes in the area must be removed, according to new international study.
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Researchers have investigated how different subtypes of essential immune-response cells called CD8+ T lymphocytes cooperate to mount a stronger anti-tumor response. The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory…
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