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A new syndrome caused by biallelic mutations -- those produced in both gene copies inherited from the mother and father -- in the FANCM gene predisposes the body to the appearance of tumors and causes rejection to chemotherapy treatments. Contrary…
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Scientists discover several alterations in this cellular process with implications in cancer by analyzing samples from more than 4,000 patients.
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Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use…
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A new, publicly available test to assess the safety of cell therapy products altered by lentivirus generates results within a few hours, potentially hastening the pace at which viral immunotherapies move into clinical trial. Current assays required by the US…
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Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now. In a new paper, researchers identified exosomes -- extremely small vesicles…
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Researchers have discovered a mechanism through which mitochondria, the energy factory of our body's cells, play a role in preventing cells from dying when the cells are deprived of nutrients -- a finding that points to a potential target for…
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A diet that includes plenty of colorful vegetables and fruits may contain compounds that can stop colon cancer and inflammatory bowel diseases in pigs, according to an international team of researchers. Understanding how these compounds work on a molecular level…
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Researchers have discovered a new genetic test which could help predict cancer recurrence - paving the way for more precise, personalised treatments.
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Children diagnosed with inflammatory bowel disease have an increased risk of cancer, especially gastrointestinal cancers, both in childhood and later in life, finds a study.
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A team of chemical engineers, inspired by the way that cells translate their own mRNA into proteins, has designed a synthetic delivery system that is four times more effective than delivering mRNA on its own.
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The growth of certain aggressive brain tumors can be halted by cutting off their access to a signaling molecule produced by the brain's nerve cells, according to a new study.
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Microprotein helps cells choose best path to repair genes and avoid cancer, scientists have discovered.
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Training at altitude – meaning under low-oxygen conditions – turns athletes into super-performers. Likewise, Prof. Guy Shakhar has found, oxygen-starved T cells become super-effective at attacking cancer. These T cells could provide an immediate way to improve cancer immunotherapy.
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Opening up a new pathway to fight cancer, researchers have found a way to target an enzyme that is crucial to tumor growth while also blocking the mechanism that has made past attempts to target that enzyme resistant to treatment.…
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Raw broccoli sprouts, a rich source of potential cancer-fighting compounds, have become a popular health food in recent years. But conventional heat treatment used to kill bacteria on produce can reduce levels of the broccoli sprouts' helpful phytochemicals. Now researchers…
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Human papillomavirus (HPV) testing detects a higher number of precancerous cervical lesions than cytology-based Pap smears in a female population including a proportion offered HPV vaccination, according to a new study.
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It is estimated that up to 75 percent of breast cancer survivors experience problems with cognitive difficulties following treatments, perhaps lasting years. Currently, few science-based options are available to help. Researchers report in a pilot study of 87 female breast…
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A new mechanism by which cancer cells evade destruction by the immune system has been discovered by a team of researchers. Their paper describes how immune cells known as group 2 innate lymphoid cells (ILC2s) are recruited by leukemic cells…
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Immune-cell based therapies opening a new frontier for cancer treatment carry unique, potentially lethal side effects that provide a new challenge for oncologists, one addressed by proposed guidelines for systematically dealing with the toxicities of these drugs.
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Stem cells control the cells around them, inducing them to perform specific functions. This phenomenon of the "language of stem cells", which has now been discovered for the very first time, report investigators.
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