Martin Gore, PhD, FRCP, CBE from the Royal Marsden NHS Foundation, London, UK discusses the resurgence of immunotherapy in the treatment of cancer at the European Cancer Congress of the European Cancer Organisation (ECCO) 2017 in Amsterdam, Netherlands. Until recently, immunotherapy was not a common treatment, however, immune checkpoint inhibitors, as well as CAR T-cell therapy have changed the nature of the game. These new immunotherapies are improving overall survival in a large proportion of patients, even those with metastatic disease. The next steps now are to determine whether combinations, such as adding radiotherapy, any further improve survival benefit.