Thomas Powles, MBBS, MRCP, MD, from Barts Cancer Institute, London, UK, discusses the RANGE trial, a Phase III clinical trial investigating the effectiveness of ramucirumab in treating bladder cancer (NCT02426125). He raises the possibility of applying chemotherapy, immunotherapy and targeted therapy in future treatment of cancer and states that current research must be focused on investigating these forms of therapies in combination to evaluate their effectiveness. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.