PD-L1 agents in the treatment of NSCLC

David Gandara, MD, from the University of California, Davis, CA discusses the results of the OAK trial (NCT02008227) and how they impact the treatment landscape of advanced stage, non-small cell lung cancer (NSCLC). This is the first phase III trial to investigate the safety and efficacy of the anti-PD-L1 agent, atezolizumab, compared to docetaxel, in patients with NSCLC. The results indicated that there were better patient outcomes when the received atezolizumab, and this was also associated with high expression of PD-L1. Interestingly, even patients with no expression of PD-L1, showed some clinical benefit. This interview was recorded at the annual meeting of the European Lung Cancer Conference (ELCC) 2017, Geneva, Switzerland.

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