Martin Reck, MD, PhD from the Lungen Clinic Grosshansdorf, Grosshansdorf, Germany discusses highlights from the keynote lecture on the genetic landscape of lung cancer. The genetic changes between adenocarcinoma and squamous cell carcinoma were detailed in the lecture as well as challenges faced by physicians. In addition, the lecture included potential future developments, such as the response of immunotherapies to certain genetic changes. This interview was recorded at the annual meeting of European Lung Cancer Conference (ELCC) 2017 in Geneva, Switzerland.