NCRI 2016 | Car brakes: PD-1/PD-L1 molecular pathway explained
Lieping Chen, MD, PhD of Yale School of Medicine, New Haven, CT discusses the PD-1/PD-L1 molecular pathway. The two molecules regulate immune response and control inflammation, acting similarly to a brake in a car. Cancer cells use this mechanism and amplify it to escape the immune system response and continue growing. Anti-PD-1 and anti-PD-L1 drugs developed to counteract this action are effective in 30% of solid tumors. Prof. Chen points out that further work is required to discover new treatments. Recorded at the 2016 National Cancer Research Institute (NCRI) Conference in Liverpool, UK.
Get great new content delivered to your inboxSign up