ASCO GI 2023 | Is front-line anti-EGFR therapy essential in RAS-WT mCRC?

Ardaman Shergill, MD, University of Chicago, Chicago, IL, talks on the role of first-line EGFR antibodies in patients with metastatic RAS wild-type colorectal cancer. The Phase III PARADIGM (NCT02394795) and STRATEGIC-1 (NCT01910610) trials received anti-EFGR therapies in later line settings, which necessitates further research in the potential efficacy of first-line anti-EGFR antibodies. Significant clinical toxicity and financial considerations observed in existing studies, such as the CAIRO5 study (NCT02162563), suggests that anti-EGFR agents are preferable in pretreated patients. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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