Jeanne Tie, MBChB, FRACP, MD, Peter MacCallum Cancer Centre and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, describes applications of liquid biopsies in clinical practice, highlighting use in early disease, afanced disease and screening. Prof. Tie also touches on the potential of ctDNA to guide treatment management in patients with cancer. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.