ESMO 2022 | Effect of peri-tumoral infiltration of local anesthetic prior to surgery on survival in early BC

Rajendra Badwe, MD, Tata Memorial Hospital, Mumbai, India, discusses a multi-center randomized trial to test the impact of peri-tumoral infiltration of local anesthesia (LA) before surgery on survival in women with early breast cancer. The primary endpoint was disease-free survival (DFS) and the secondary endpoint was overall-survival (OS). The study included 1600 patients randomized to LA or no LA. At 72 months, there were 109 DFS in the LA arm and 146 in the no-LA arm. At 6-years DFS rates were 86.1% and 81.7% in LA and No-LA arms, respectively and OS was 89.9% and 86.2%, respectively. The trial demonstrated peri-tumoral injection of lidocaine before surgery can reduce 1 of 4 recurrences and 3 of 10 deaths in women with early breast cancer. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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