SABCS 2024 | Molecular and immune profiling of metaplastic and invasive ductal TNBC

Pooja Advani • 13 Dec 2024

SABCS 2024

Breast Cancer

Pooja Advani, MBBS, MD, Mayo Clinic, Jacksonville, FL, discusses the distinct molecular and immune signatures of metaplastic triple-negative breast cancer (M-TNBC) compared to invasive ductal TNBC (ID-TNBC). Higher frequencies of mutations in PIK3CA, PTEN, and TERT in M-TNBC were observed, alongside reduced immune cell infiltration and lower IFNγ scores. There was additionally no statistical difference in incidences of both types of TNBC across difference ethnic groups. These insights highlight the need for targeted therapeutic strategies. This interview took place at the 2024 San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.