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SABCS 2024 | Evaluating the clinical significance of PDX models in breast cancer research

Jonathan Lei • 12 Dec 2024
SABCS 2024
Breast Cancer

Jonathan Lei, PhD, Baylor College of Medicine, Houston, TX, comments on the clinical relevance of patient-derived xenografts (PDXs) in breast cancer research. PDX models demonstrate an 80% concordance with patient responses to taxane therapies, making them valuable tools for studying treatment efficacy. Despite their advantages, the absence of an immune system in PDX models limits their utility in evaluating immune-related therapies. This interview took place at the 2024 San Antonio Breast Cancer Symposium (SABCS) congress in San Antonio, TX.

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