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ASCO 2025 | Kidney cancer highlights from ASCO 2025

Eric Jonasch, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses key takeaways in renal cell carcinoma from the American Society of Clinical Oncology (ASCO) Annual Meeting, highlighting zanzalintinib plus immunotherapy combination data in frontline treatment, while awaiting major Phase III trial readouts. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So this is not a year for ASCO where we’re seeing a lot of breakthroughs in renal cell carcinoma. We are seeing, for example, a combination of lenvatinib plus immunotherapy in the front-line setting showing some promising data, which gives us some hope that perhaps lenvatinib is going to be an agent that’s going to make it into general usage as the clinical trials move forward...

So this is not a year for ASCO where we’re seeing a lot of breakthroughs in renal cell carcinoma. We are seeing, for example, a combination of lenvatinib plus immunotherapy in the front-line setting showing some promising data, which gives us some hope that perhaps lenvatinib is going to be an agent that’s going to make it into general usage as the clinical trials move forward. Beyond that really I think we’re just waiting for the late major readouts from the large phase 3 studies that are still underway at the moment.

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Disclosures

Consulting or Advisory Role – Aveo; Eisai; Exelixis; GlaxoSmithKline; Ipsen; Merck; NiKang Therapeutics; Novartis; Takeda; Telix Pharmaceuticals
Research Funding – Abbvie (Inst); Arrowhead Pharmaceuticals (Inst); Aveo (Inst); Corvus Pharmaceuticals (Inst); Merck (Inst); NiKang Therapeutics (Inst); ProfoundBio (Inst); Telix Pharmaceuticals (Inst)
Travel, Accommodations, Expenses – Pfizer