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ASCO 2025 | The role of OFS for BRCAm patients receiving adjuvant PARP inhibition

Paola Zagami, MD, European Institute of Oncology IRCSS (IEO), Milan, Italy, discusses study limitations regarding ovarian function suppression (OFS) in breast cancer treatment. Dr Zagami explains that PARP inhibitors were not approved when the study was conducted, so no patients received this treatment combination. While the data supports using OFS early in adjuvant therapy, the findings cannot be extended to patients receiving adjuvant PARP inhibitors since that data wasn’t collected in this particular study.This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

This is a very important question. You have to know that there is a limitation in this study, because when we created and took this study, the use of adjuvant PARP inhibitor was not yet approved, so there are no patients that received adjuvant PARP inhibitor in this setting. But for sure, the use of a vascular suppression in the first part of the adjuvant treatment is very important and now we have this data that support the use of this...

This is a very important question. You have to know that there is a limitation in this study, because when we created and took this study, the use of adjuvant PARP inhibitor was not yet approved, so there are no patients that received adjuvant PARP inhibitor in this setting. But for sure, the use of a vascular suppression in the first part of the adjuvant treatment is very important and now we have this data that support the use of this. We cannot enlarge these results also in the population that receive adjuvant PARP inhibitor because we have not the data in this moment.

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