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ESMO Gynae 2025 | TRUST: optimal timing of surgical therapy in advanced ovarian cancer

Christina Fotopoulou, MD, PhD, Imperial College London, London, UK, discusses the TRUST study (NCT02828618), a prospective randomized trial on the timing of surgery in advanced ovarian cancer. Despite high tumor loads, optimal or maximized effort surgery resulted in similar overall survival rates among patients. However, progression-free survival was significantly better in the primary debulking arm. This interview took place at 2025 European Society for Medical Oncology (ESMO) Gynaecological Cancers Congress in Vienna, Austria.

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