In this episode of VJOncology podcasts, we present highlights from the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. Five leading experts share key data and insights spanning prostate cancer, sarcoma, lung cancer, colorectal cancer, and breast cancer. Dr Mary-Ellen Taplin from Dana-Farber Cancer Institute presents final analysis data from the PROTEUS trial, demonstrating that perioperative apalutamide plus androgen deprivation therapy (ADT) sets a new standard of care in high-risk localized prostate cancer. Dr Maggie Zhou from Stanford University highlights practice-changing findings in sarcoma, including the SARC041 trial of abemaciclib in dedifferentiated liposarcoma. Dr Abdul Rafeh Naqash from the University of Oklahoma Health Sciences Center reviews key lung cancer advances, including results from the DeLLphi-304, LIBRETTO-432, and ALCHEMIST trials. Dr Scott Kopetz from MD Anderson Cancer Center presents progression-free and overall survival data from BREAKWATER Cohort 3, supporting encorafenib plus cetuximab combined with FOLFIRI as a new standard of care in BRAF V600E-mutant metastatic colorectal cancer. Finally, Dr Kevin Kalinsky from Emory University discusses PFS2 data from ASCENT-04, reinforcing sacituzumab govitecan plus pembrolizumab as a standard of care in treatment-naive PD-L1-positive metastatic triple-negative breast cancer. This episode offers essential insights into practice-changing data across five major tumor types from one of the most important oncology meetings of the year.