In this week’s VJOncology podcast, we present highlights in genitourinary cancer from the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. Join Andrew Armstrong of Duke University Medical Center, Srikala Sridhar of the Princess Margaret Cancer Centre, Tian Zhang of UT Southwestern Medical Center, and Lucia Nappi of the University of British Columbia as they discuss key data and clinical perspectives across prostate, bladder, kidney and testicular cancer, including the PROTEUS, CHAMP, TALAPRO-3, A-DREAM and SWOG S1823 trials, as well as the role of enfortumab vedotin and pembrolizumab in bladder cancer.