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ESMO 2026 | Mechanisms of resistance to ARPIs in prostate cancer

Alice Bernard-Tessier • 26 Oct 2026
ESMO 2026
Genitourinary Cancer Prostate Cancer

Alice Bernard-Tessier, MD, Institut Gustave Roussy, Villejuif, France, discusses the mechanisms of resistance to androgen receptor pathway inhibitors (ARPIs), noting that approximately 60-80% of patients treated with ARPIs develop AR alterations, including amplification, mutation, and rearrangements. Dr Bernard-Tessier highlights that these alterations do not necessarily mean the tumor is no longer driven by the androgen receptor, and that the impact of these changes on novel AR-targeted drugs is still being explored. This interview took place at the European Society for Medical Oncology (ESMO) 2026 Congress in Madrid, Spain.

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