Monika Krzyzanowska, MD, MPH Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, discusses the AToM trial (NCT02485678). This study is a pragmatic cluster-randomized trial of ambulatory toxicity management in patients receiving adjuvant or neo-adjuvant chemotherapy for early-stage breast cancer. This study evaluated the effectiveness of proactive toxicity management intervention in a care setting. The primary outcome for this study was the mean number of emergency department visits or hospitalizations per patient. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).