Alistair Grey, FRCS (Urol), University College London, London, UK, discusses the ongoing efforts in prostate cancer to improve stratification using newer biomarkers. A more accurate stratification model may enable less invasive treatment of men with less aggressive disease. Dr Grey also highlights the potential of improved stratification to identify more patients suitable for active surveillance. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.