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New research shows that it may be possible to freeze cancer cells and kill them where they stand.
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Combinations of cancer drugs can be quickly and cheaply tested on tumour cells using a novel device developed by scientists. The research marks the latest advancement in the field of personalized medicine.
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The work has important implications for understanding how human cancer cells develop resistance to natural product-based chemotherapies.
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An analysis has linked higher body mass index, or BMI, to lower breast cancer risk for younger women, even for women within a normal weight range.
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A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. This is the first such synthetic enzyme to…
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Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes -- tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study could lead to new therapies that stop tumor growth and…
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A discovery about how human cells are 'triggered' to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders. A research team has identified the molecular trigger in human cells…
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The bottleneck of cationic antimicrobial peptides as anticancer therapeutics is their limited ability to penetrate cell membranes. Researchers discovered a cyclic decapeptide (termed peptide 1) that serves as a promising lead compound as a new intracellular delivery vehicle for therapeutically…
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How can elimination of therapeutics from the bloodstream or their early enzymatic degradation be avoided in systemic delivery? Scientists have new developed a method to bind an established cancer therapeutic, floxuridine, with natural serum albumin for its transport and delivery…
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Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report.
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Giving the drug sodium thiosulphate after chemotherapy reduces hearing loss in children treated for liver cancer, according to new findings.
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Researchers discovered how oncogenic mutant cells selectively expand into surrounding normal tissues and occupy them based on prediction by computer simulation and experimental verification.
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A study offers insight into the weight loss seen in pancreatic cancer patients, and suggests that weight loss may not necessarily affect patients' survival.
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To understand the biology of diseased organs researchers can use different types of molecular data. One of the biggest computational challenges at the moment is integrating these multiple data types. A new computational method jointly analyses different types of molecular…
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Researchers have revealed that malignant melanoma can reprogram their protein synthesis machinery and become addicted to a new family of enzymes that modify transfer RNAs during acquired resistance. The inhibition of these molecules synergies with targeted therapies to produce a…
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The majority of existing simulation studies show that the parts of the brain with high connectivity, the so-called 'hubs', are most important when it comes to several different cognitive tasks. But the results of a rare in-vivo study demonstrates that…
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A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes. It enables researchers to study concurrent processes within cells and tissue, and could give cancer researchers a new tool for…
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A groundbreaking discovery has identified previously unknown therapeutic targets that could be key to preventing the spread of cancer. Researchers found that by inhibiting several newly identified gene targets they could block more than 99.5 per cent of cancer metastasis…
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Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found.
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Researchers have developed a computer program which has revealed a previously unknown combination of drugs that may be the answer to Triple Negative Breast Cancer (TNBC), using genetic and treatment data from TNBC cells grown in labs and from hundreds…
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