Sung-Bae Kim, MD, PhD, Asan Medical Center, Seoul, Republic of Korea, shares a summary of his talk on the optimal adjuvant and neoadjuvant chemotherapy combinations for the treatment of triple-negative breast cancer (TNBC), highlighting differences in the treatment of subtypes with or without germline BRCA (gBRCA). Prof. Kim outlines the role of pathological complete response (pCR) as a predictive marker and comments on the use of platinum-based chemotherapy and PARP inhibitors. This interview took place at the virtual European Society for Medical Oncology (ESMO) Breast Cancer Congress 2021.