Natasha Leighl, BSc, MMSc, MD, Cancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Canada, discusses the practical challenges of implementing widespread liquid biopsy testing for lung cancer. She highlights key considerations, such as assay sensitivity and false positives, and the importance of guidance and support when interpreting test results.This interview took place at the 18th British Thoracic Oncology Group (BTOG) 2020 congress held in Dublin, UK.