Kyrollis Attalla, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the findings of a study describing the prevalence and landscape of actionable genomic alterations in renal cell carcinoma (RCC). Leading altered genes included TSC1 mutation, PIK3CA mutation and MET amplification. This interview took place at the 2020 Genitourinary Cancers Symposium, held in San Francisco, CA.