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GU Cancers 2026 | Identifying patients with prostate cancer who will benefit from radium-223

Enrique Gallardo, MD, Parc Taulí University Hospital, Barcelona, Spain, highlights the challenges of selecting patients for treatment and the potential of molecular imaging techniques, such as PSMA PET-CT, to identify patients with prostate cancer at an early stage. These techniques could help to address the current lack of molecular markers for patient selection, similar to their use in localized prostate cancer. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

At present, there is no molecular marker that could help us to select these patients. The inclusion criteria of the PS3 trial specified at least two bone lesions detected by conventional imaging techniques. So in our present situation with molecular imaging incorporating more and more quickly into clinical practice, it’s difficult to interpret if these patients are the same population as in the study...

At present, there is no molecular marker that could help us to select these patients. The inclusion criteria of the PS3 trial specified at least two bone lesions detected by conventional imaging techniques. So in our present situation with molecular imaging incorporating more and more quickly into clinical practice, it’s difficult to interpret if these patients are the same population as in the study. But in the same way as in localized prostate cancer, we use molecular techniques to decide on treatment. Probably these molecular techniques, PSMA, PET-CT, and so on, could help us to identify patients in an early fashion. So I think this could be the answer for this kind of patient.

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