WCLC 2023 | KRYSTAL-1: adagrasib in NSCLC patients with CNS metastases

Marcelo Negrao, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the results of the Phase Ib KRYSTAL-1 trial (NCT03785249) which looked into the intracranial activity of adagrasib in patients with non-small cell lung cancer (NSCLC) with stable, untreated CNS metastases. Adagrasib demonstrated promising and durable CNS activity in patients with untreated CNS metastases, where response rates were achieved in almost half of patients. This interview took place at the 2023 World Conference on Lung Cancer (WCLC) in Singapore, Singapore.

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