Javier Garcia-Corbacho, MD, Hospital Clinic Barcelona, Barcelona, Spain, discusses the first results of the CLIMB360 study, a prospective molecular screening program accross multiple cancer types based on circulating tumor DNA (ctDNA). In this study it was found that real-time and prospective genomic profiling of patients with advanced cancer using ctDNA is feasible, fast and helps to identify therapeutic targets approved or evaluated in clinical trials. This interview took place at the European Society for Medical Oncology (ESMO) 2021 congress.