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GU Cancers 2026 | How can belzutifan combinations reshape post-ICI kidney cancer care?

Chris Labaki, MD, Dana-Farber Cancer Institute, Boston, MA, comments the potential of belzutifan as a monotherapy and in combination with other treatments in kidney cancer. The LITESPARK-011 trial (NCT04586231) demonstrated the benefit of belzutifan with lenvatinib versus cabozantinib in patients previously treated with immune checkpoint inhibitors. Data from this trial will provide valuable insights into the role of belzutifan-based combinations with tyrosine kinase inhibitors (TKIs) in the treatment algorithm. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

I think, you know, belzutifan can be used as a monotherapy, but also in combination. And in the setting of, you know, ASCO-GU 2026, it’s important to point out the presentation that will be done tomorrow around LITESPARK-011, which is a combination of belzutifan with lenvatinib versus cabozantinib in patients who were previously treated with immune checkpoint inhibitors...

I think, you know, belzutifan can be used as a monotherapy, but also in combination. And in the setting of, you know, ASCO-GU 2026, it’s important to point out the presentation that will be done tomorrow around LITESPARK-011, which is a combination of belzutifan with lenvatinib versus cabozantinib in patients who were previously treated with immune checkpoint inhibitors. And I think the data from this aspect will help better shed light on the role of belzutifan, especially belzutifan-based combination, along with TKIs, and better understanding where does this fit within the treatment algorithm.

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