ASCO 2023 | PROSPECT: neoadjuvant CRT vs FOLFOX in locally advanced rectal cancer

Olatunji Alese, MD, Emory Winship Cancer Institute, Atlanta, GA, discusses findings from the Phase III PROSPECT trial (NCT01515787) of neoadjuvant chemoradiation (CRT) versus neoadjuvant FOLFOX chemotherapy, followed by total mesorectal excision (TME) in patients with locally advanced rectal cancer (LARC). The study demonstrated clinical benefit for neoadjuvant FOLFOX, where patients can avoid chemoradiation and subsequently receive surgery. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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