Luca Magnani, PhD, Imperial College London, London, UK, talks on the link between endocrine therapy and dormancy in hormone-dependent breast cancer, highlighting the role of epigenetics. Dr Magnani comments on the impact of epigenetic decay and the resulting escape from dormancy by cancer cells, describing the potential consequences on precision medicine. This interview took place at the virtual European Society for Medical Oncology (ESMO) Breast Cancer Congress 2021.