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GU Cancers 2026 | Clinical and demographic disparities in prostate cancer surgery utilization

Manas Pustake, MBBS, Texas Tech University Health Science Center, El Paso, TX, discusses a retrospective analysis of the surveillance, epidemiology, and end results database from 2000 to 2022 involving over 1.2 million men with prostate cancer. Advanced age, distant metastases, unmarried status, and more recent diagnosis years were associated with decreased radical prostatectomy utilization. Conversely, regional disease and higher income predicted increased surgical rates. Persistent racial and socioeconomic disparities suggest a need for targeted interventions to ensure equitable access to surgical management for localized prostate cancer. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

So this is an important topic and as we know our radical prostatectomy remains the cornerstone of management for regional prostate cancer but you know there are many factors which affect the utilization and surgical candidacy for patients with prostate cancers some of them are able to go for prostatectomy some are not. That’s why we undertook this study to address this research question, like what are the clinical and demographic factors which predict the utilization of radical prostatectomy in patients diagnosed with prostate cancer...

So this is an important topic and as we know our radical prostatectomy remains the cornerstone of management for regional prostate cancer but you know there are many factors which affect the utilization and surgical candidacy for patients with prostate cancers some of them are able to go for prostatectomy some are not. That’s why we undertook this study to address this research question, like what are the clinical and demographic factors which predict the utilization of radical prostatectomy in patients diagnosed with prostate cancer. So for this study, we used the SEER database spanning from 2000 to 2022, and we extracted about 1.2 million patients diagnosed with prostate cancer. And we did a multivariate logistic regression to see what factors, what specifically the demographic, clinical, and socioeconomic factors predict the utilization of radical prostatectomy in these patients. And the results we found were interesting so the first factor that we found was age as patients’ age was higher there was a 10 percent less likelihood of receiving prostatectomy the second factor that we found was a temporal association that starting from 2000 to 2022, each year the utilization of prostatectomy decreased by like 5% every year from 2000 to 2022. So there could be multiple reasons for that. Maybe preference for alternative therapies like radiation or some other therapies might have contributed to it. The other factors that we found were patients who were married versus unmarried were twice as likely to receive the prostatectomy versus the unmarried people, which was an interesting result. Also, people who were residing in high-income zip quartiles were more likely to utilize the prostatectomy versus those who were residing in low-income zip codes. So another factor was which was very expected that the regional disease had 12 times more odds of receiving prostatectomy versus the patient with metastatic disease. So these are the core findings which we found from our study and there are a few take-home points from the study that you know the utilization of prostatectomy has decreased although like by five percent every year over the last couple of decades there might be multiple factors but the disparities exist between like age and people who are married and people of certain race and ethnicities. So we need to do targeted intervention to address those disparities and reduce them.

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