Yelena Y. Janjigian, MD, Memorial Sloan Kettering Cancer Center, New York, NY, outlines the results of comprehensive molecular profiling of esophagogastric cancer patient-derived xenografts which were found to accurately recapitulate the genomic heterogeneity and tumor biology of patients with esophagogastric cancer. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).