ASCO 2023 | HRQoL in KEYNOTE-966: pembrolizumab with gemcitabine and cisplatin for advanced biliary tract cancer

In the Phase 3 KEYNOTE-966 trial (NCT04003636), the addition of pembrolizumab to gemcitabine/cisplatin as first-line therapy for unresectable locally advanced or metastatic biliary tract cancer (BTC) significantly improved overall survival (OS) with a manageable safety profile. In this update, Changhoon Yoo, MD, PhD, Asan Medical Center, Seoul, Korea, discusses exploratory patient-reported outcomes (PROs) from KEYNOTE-966. PROs were assessed using various questionnaires, and the analysis showed that health-related quality of life (HRQoL) was maintained with pembrolizumab + gemcitabine/cisplatin treatment. These PRO results, along with the efficacy and safety data, support pembrolizumab + gemcitabine/cisplatin as a new first-line treatment option for advanced BTC. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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