Janet Kukreja, MD, MPH, University of Colorado, Boulder, CO, talks on the unmet needs for patients with upper tract urothelial carcinoma (UTUC), highlighting the requirement of biomarkers for treatment decision making, as well as the difficulty in gaining access to the tumors. Additionally, there is a lack in perioperative imaging which would further help decipher which treatments are most suitable for patients. This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.