Speaking from the European Society for Medical Oncology (ESMO) 2019 congress in Barcelona, Spain, Arlene Siefker-Radtke, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses the ongoing phase 3 KEYNOTE-866 study (NCT03924856). This trial is investigating perioperative pembrolizumab in combination with neoadjuvant chemotherapy in cisplatin-eligible patients wth muscle-invasive bladder cancer.