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ESMO 2023 | Advanced ctDNA assay for pre-op lung cancer stratification

Federica Di Nicolantonio, PhD, University of Torino, Turin, Italy, discusses the breakthroughs in ctDNA detection using the NeXT Personal platform. The ultra-sensitive approach achieved consistent detection thresholds within 1-3 parts per million with over 99.95% specificity. In a cohort of early-stage lung cancer patients, ctDNA was pre-operatively detected in 81% of lung adenocarcinomas (LUADs), correlating with overall and relapse-free survival. Notably, even low ctDNA levels below 80 PPM, the 95% limit of detection, indicated reduced overall survival. The NeXT Personal platform shows promise for advanced stratification and guiding adjuvant therapy in early-stage ctDNA-positive disease. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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