In early-stage cancer diagnostics, low yields of extracted cell-free DNA (cfDNA) from plasma have hindered the development of liquid biopsies in this patient population. Filip Janku, MD, PhD, MD Anderson Cancer Center, TX, discusses the development of a liquid-phase-based DNA extraction method that enriches for cfDNA. This approach provides improved cfDNA mutation detection by increasing cfDNA recovery and reducing contaminating genomic DNA background. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.