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ESMO WCGIC 2023 | Precision medicine approaches in pancreatic cancer

Philip Philip, MD, PhD, FRCP, Wayne State University School of Medicine/Henry Ford Health, Detroit, MI, discusses the feasibility of precision medicine in pancreatic cancer. There are currently known mutations that can be targeted in pancreatic cancer, and next-generation sequencing (NGS) enables the identification of treatable mutations in patients. Additional research is needed to elucidate less common mutations that will results in the development of novel therapies. This interview took place at the ESMO World Congress on Gastrointestinal Cancer (WCGIC) 2023 in Barcelona, Spain.

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Transcript (edited for clarity)

We are. We aren’t too far, but we’re not too close either. We are close in a sense that there are things we can do now. And I refer to for example, if you look at some of the genes that mutated, we can prescribe certain drugs. I talked about we have started and I look at the NGS, for example, as a very first and important step in moving towards that...

We are. We aren’t too far, but we’re not too close either. We are close in a sense that there are things we can do now. And I refer to for example, if you look at some of the genes that mutated, we can prescribe certain drugs. I talked about we have started and I look at the NGS, for example, as a very first and important step in moving towards that. So we have already started the process. The process has already started and there is nothing more than pancreatic cancer that deserves a personalized treatment because it’s a disease that we don’t have good treatments. It’s a matter of looking for mutations. Some of them are rare mutations. There may be rare, but but for a patient it’s very valuable and unless you look for it, you will not find it. So the short answer is yes. There are options now for patients to go into a personalized treatment, kind of mental or strategy And there is definitely a room for that and it already started, but it’s a matter of people trying to buy into it and believe in the fact that there might be rare chances to some patients. But at the same time anything is worth for a patient because especially in a disease like this where the alternatives aren’t good alternatives as we call them, alternatives in terms of standards of care, because even in patients who we see them who are curable, like they have localized disease and then we do surgery, unfortunately a good number of those patients will have a recurrence of the disease and most of them will die of it. So anything we do, anything we do to help the patients will be important. Even if we’re talking about very small percentages who may today go on a personalized treatment. But that’s increasing with time it’s going. So maybe if I come back in five years time, it will be much more of that happening. But now it’s still it is happening. It’s not like it’s not happening.

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