AACR 2024 | ACTION: ONC201 in H3 K27M–mutant diffuse midline glioma

Patrick Wen, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the Phase III ACTION trial (NCT05580562), evaluating ONC201 (dordaviprone) in H3 K27M–mutant diffuse midline glioma. H3 K27M-mutant diffuse gliomas are typically inoperable and insensitive to chemotherapy, where current treatment only consists of radiotherapy, with poor prognosis. ONC201 is a dopamine receptor D2/3 inhibitor that demonstrates a durable and good response rate in patients with mutant diffuse midline glioma. This interview took place at American Association for Cancer Research (AACR) Annual Meeting 2024 in San Diego, CA.

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