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ASCO 2025 | Phase III trial of catequentinib in pretreated leiomyosarcoma

Robin Jones, MBBS, MRCP, MD, Institute of Cancer Research, London, UK, discusses a Phase III trial (NCT03016819) of catequentinib in patients with advanced or metastatic leiomyosarcoma requiring third-line or later treatment. Catequentinib significantly improved progression-free survival compared to placebo, with consistent benefit observed in those with fewer prior therapies. Common treatment-related adverse events included gastrointestinal symptoms, fatigue, and hypertension. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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