BTOG 2023 | ETOP clinical trials in EGFR-, KRASG12C- and ALK-mutated NSCLC

Rolf Stahel, MD, ETOP IBCSG Partners Foundation, Berne, Switzerland, discusses the latest clinical research from the European Thoracic Oncology Platform (ETOP), in the EGFR-m positive, KRASG12C+ and ALK+ space, including the STEREO trial which is a multicentre single-arm phase II trial assessing the safety and efficacy of first-line osimertinib and locally ablative radiotherapy in patients with synchronous oligo-metastatic EGFR-mutant non-small cell lung cancer (NSCLC). In addition, Dr Stahel also speaks on the AMAZE-lung trial (NCT05601973) which is evaluating amivantamab, lazertinib plus bevacizumab in patients with EGFR-mutant advanced NSCLC with progression on previous third-generation EGFR-TKI. And in the KRASG12c-mutant NSCLC field, Dr Stahel highlights the ongoing ADEPPT trial (NCT05673187) assessing the clinical efficacy of adagrasib in patients with KRASG12C-mutant NSCLC, including the elderly (≥70 years) or patients with poor performance status. This interview took place at the British Thoracic Oncology Group (BTOG) Annual Conference 2023 in Belfast, UK.

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