Julien Taieb, MD, PhD, European Hospital Georges Pompidou, Paris, France, discusses the need for larger studies to confirm the use of circulating tumor DNA (ctDNA) as an indicator of minimal residual disease (MRD) in patients with colon cancer. This interview took place at the European Society for Medical Oncology World Congress on Gastrointestinal Cancer (ESMO WCGIC) 2022 in Barcelona, Spain.