James Eastham, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses moving prostate cancer treatments to earlier in the disease course. Specifically, he focuses on whether the integration of systemic and localized treatment for a multimodal strategy is effective for patients with high-risk localized prostate cancer. This interview took place at the 2020 Genitourinary Cancers Symposium, held in San Francisco, CA.