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ESMO 2022 | DATA: anastrozole in patients with HR+ breast cancer following adjuvant tamoxifen

Vivianne Tjan-Heijnen, MD, PhD, Maastricht University, Maastricht, the Netherlands, describes the trial design of the Phase III DATA trial (NCT00301457), which assessed various durations of anastrozole in patients with hormone receptor-positive breast cancer who were disease-free after 2-3 years of adjuvant tamoxifen. Patients were stratified by nodal status, hormone receptor status, HER2 status and duration of prior tamoxifen treatment. The primary endpoint was adapted disease-free survival (aDFS) and the secondary endpoint was adapted overall-survival (aOS), with the median adapted follow-up time being 10.1 years. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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