Roisin Connolly, MD, University College Cork, Cork, Ireland outlines the RxPONDER trial (NCT01272037) which supports the paradigm of moving away from chemotherapy in post-menopausal patients with 1-3 positive lymph nodes and touches on the next questions in the treatment and management of breast cancer. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).