Reinhard Dummer, MD, PhD, University Hospital Zürich, Zürich, Switzerland, highlights the importance of molecular profiling in melanoma and describes his experiences with integrating it into routine clinical practice. He describes the Tumor Profiler program in Zurich, which is an interdisciplinary approach that aims to investigate many features of a tumor and facilitate selection of appropriate immunotherapeutic approaches. The program involves the use of several platforms including next-generation genetic sequencing, digital pathology, high-resolution profiling technologies and platforms for drug response profiling. This interview took place during the 10th World Congress of Melanoma in conjunction with the 17th EADO Congress Interactive Virtual Meeting.