ASCO GI 2024 | ARTEMIS-PC: personalized panel for circulating tumor DNA in pancreatic cancer

Edward D. Esplin, MD, PhD, Invitae, San Francisco, CA discusses the urgent need for innovative diagnostic and therapeutic approaches in pancreatic cancer (PC). Current challenges include the low sensitivity of circulating tumor DNA (ctDNA) assays in PC due to its high stromal and low cellular features. The Invitae Personalized Cancer Monitoring™ test, a novel and highly sensitive tumor-informed minimal residual disease (MRD) detection assay, is introduced. The ARTEMIS-PC study (NCT06043921), a prospective observational trial in Japan, aims to assess the clinical utility of this assay in 150 patients with resectable and unresectable PC. Primary and secondary endpoints include the success rate of creating personalized panels, concordance of KRAS mutations, and ctDNA positivity rates at various stages. The study commenced enrollment in December 2022. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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