Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ESMO 2025 | The potential of spatial biology & clonal evolution mapping to transform precision cancer treatment

Charlotte Spencer, PhD, The Francis Crick Institute, London, UK, discusses the potential of spatial biology and clonal evolution mapping to transform precision cancer treatment, highlighting the need for further studies to link genetic evolutionary factors with tissue morphology. Dr Spencer emphasizes that understanding clonal involution and its impact on patient outcomes has improved significantly over the last decade, and integrating this knowledge with spatial biology can facilitate clinical translation. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

Yeah, so I hope that we see more of these kinds of studies over the forthcoming years. I think we have got a much more in-depth understanding over the last decade of how clonal involution impacts patient outcomes, just in terms of prognosis and in response to treatments. By linking it to spatial biology and histological patterns, that’s a mechanism of translating it into the clinic. And I think that we need more studies to try and find those links between genetic evolutionary factors and tissue morphology in order to try and get these concepts in a scalable way in the clinical setting...

Yeah, so I hope that we see more of these kinds of studies over the forthcoming years. I think we have got a much more in-depth understanding over the last decade of how clonal involution impacts patient outcomes, just in terms of prognosis and in response to treatments. By linking it to spatial biology and histological patterns, that’s a mechanism of translating it into the clinic. And I think that we need more studies to try and find those links between genetic evolutionary factors and tissue morphology in order to try and get these concepts in a scalable way in the clinical setting.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...