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ESMO 2025 | Temporal and age-related trends in colorectal cancer presentation
Emerik Osterlund, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on temporal and age-related differences in presentation mode for colorectal cancer using large-scale retrospective data enhanced by large language model classification. Findings show early-onset disease has become more common over time and is more frequently symptomatic, while screening detection in older patients has modestly increased. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.
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Transcript
This was a big AI-powered analysis of 12,000 colorectal cancer patients that were treated at MD Anderson during some point of their disease trajectory. And here we looked at the mode of presentation of these patients using AI and kind of saw that symptomatic or emergency presentation was more common in early-onset cancer compared with late-onset and that screening detection was more common in the older patients compared with the younger ones...
This was a big AI-powered analysis of 12,000 colorectal cancer patients that were treated at MD Anderson during some point of their disease trajectory. And here we looked at the mode of presentation of these patients using AI and kind of saw that symptomatic or emergency presentation was more common in early-onset cancer compared with late-onset and that screening detection was more common in the older patients compared with the younger ones. And we were also able to see some differences in the symptomatology with the younger patients having more rectal bleeding and abdominal pain and changes in bowel habits compared to the older patients that more often had anemia and other constitutional symptoms.
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