The tertiary lymphoid structure or TLS are lymphoid organs that form within tumors and they have been historically associated with a good prognosis in solid tumors. Recently in sarcomas, we identified the subpopulation of patients with TLS-positive tumors and different studies, retrospective studies, and then prospective trials confirm its role in responsiveness to immune checkpoint inhibition in soft tissue sarcomas...
The tertiary lymphoid structure or TLS are lymphoid organs that form within tumors and they have been historically associated with a good prognosis in solid tumors. Recently in sarcomas, we identified the subpopulation of patients with TLS-positive tumors and different studies, retrospective studies, and then prospective trials confirm its role in responsiveness to immune checkpoint inhibition in soft tissue sarcomas. So we intend to use this biomarker to offer immunotherapy to patients with TLS-positive sarcomas.
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