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SABCS 2022 | Window of opportunity ELIPSE trial: elacestrant in postmenopausal women with ER+HER2-/ early BC

Maria Jesús Vidal, MD, PhD, Hospital Clinic of Barcelona, Barcelona, Spain, provides an overview of the early Phase I SOLTI-1905-ELIPSE (NCT04797728) trial, a window-of-opportunity trial investigating elacestrant in a preoperative setting in postmenopausal woman with ER-positive and HER2-negative breast cancer amenable to surgery. The primary endpoint was the complete cell-cycle arrest after 4 weeks of elacestrant therapy. Overall, elacestrant was associated with a shift towards a more endocrine sensitive and less proliferative phenotype based on PAM50 gene signatures. An increase in luminal genes and decrease in proliferative genes was observed. A switch between Luminal A to Luminal B tumors was observed in 67% of patients. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.

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